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Medical Review Officers

Short Answer

A Medical Review Officer (MRO) is a licensed physician responsible for receiving laboratory drug test results, reviewing them, and making a final determination about whether a result is verified positive, negative, cancelled, refusal to test, or another outcome recognized under Part 40. The MRO is the safeguard between a laboratory's technical result and the record that reaches the employer. This article is a quick reference entry point. For a full explanation of the MRO's role, see What Does a Medical Review Officer Do?

Key Facts About the MRO Role

Definition
A licensed physician responsible for receiving and reviewing laboratory drug test results and evaluating medical explanations for certain results.
Reviewing Refusals to Test
Certain events, such as an employee failing to cooperate with the collection process or admitting to adulterating a specimen, are treated as a refusal to test. The MRO's review process intersects with these determinations.
Handling Insufficient Specimens
When an employee cannot provide a sufficient urine or oral fluid specimen, the DER, after consulting the MRO, directs the employee to a medical evaluation to determine whether a medical condition explains the failure. The MRO's consultation is part of that process.
Cancelling Tests for Fatal Flaws
The MRO cancels a test when the laboratory reports an invalid result, a rejected specimen, or certain split specimen problems, among other fatal flaws that require cancellation regardless of the specimen's testing outcome.
Correcting Fixable Problems
Some paperwork problems, such as a missing collector or employee signature on the Custody and Control Form, can be corrected without cancelling the test. The MRO's office is involved in confirming whether a correctable flaw was actually corrected.

Applicable Regulations

Professional Observation

In my experience, employees often assume the laboratory makes the final call on a drug test result. It does not. The laboratory reports a technical finding, and the MRO applies medical and regulatory judgment before that finding becomes a verified result. Understanding this distinction matters most when an employee has a legitimate medical explanation to offer, since that explanation is reviewed by the MRO, not the lab.

Related Articles

Primary Authorities

Have a Question About Your MRO Review?

If you are waiting on an MRO determination or have a medical explanation to submit, a DOT qualified Substance Abuse Professional can help you understand the process.

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Reviewed by: Perret deLapouyade, CEAP, SAP
Reviewed date: July 12, 2026
Updated date: July 12, 2026
BOK ID: BOK-0097