Medical Review Officers
Short Answer
A Medical Review Officer (MRO) is a licensed physician responsible for receiving laboratory drug test results, reviewing them, and making a final determination about whether a result is verified positive, negative, cancelled, refusal to test, or another outcome recognized under Part 40. The MRO is the safeguard between a laboratory's technical result and the record that reaches the employer. This article is a quick reference entry point. For a full explanation of the MRO's role, see What Does a Medical Review Officer Do?
Key Facts About the MRO Role
- Definition
- A licensed physician responsible for receiving and reviewing laboratory drug test results and evaluating medical explanations for certain results.
- Reviewing Refusals to Test
- Certain events, such as an employee failing to cooperate with the collection process or admitting to adulterating a specimen, are treated as a refusal to test. The MRO's review process intersects with these determinations.
- Handling Insufficient Specimens
- When an employee cannot provide a sufficient urine or oral fluid specimen, the DER, after consulting the MRO, directs the employee to a medical evaluation to determine whether a medical condition explains the failure. The MRO's consultation is part of that process.
- Cancelling Tests for Fatal Flaws
- The MRO cancels a test when the laboratory reports an invalid result, a rejected specimen, or certain split specimen problems, among other fatal flaws that require cancellation regardless of the specimen's testing outcome.
- Correcting Fixable Problems
- Some paperwork problems, such as a missing collector or employee signature on the Custody and Control Form, can be corrected without cancelling the test. The MRO's office is involved in confirming whether a correctable flaw was actually corrected.
Applicable Regulations
- 49 CFR § 40.3, Definitions (Medical Review Officer)
- 49 CFR § 40.191, Refusal to test
- 49 CFR § 40.193, Insufficient specimen procedures
- 49 CFR § 40.201, Problems that always cancel a test
- 49 CFR § 40.203, Problems that cancel a test unless corrected
Professional Observation
In my experience, employees often assume the laboratory makes the final call on a drug test result. It does not. The laboratory reports a technical finding, and the MRO applies medical and regulatory judgment before that finding becomes a verified result. Understanding this distinction matters most when an employee has a legitimate medical explanation to offer, since that explanation is reviewed by the MRO, not the lab.
Related Articles
- What Does a Medical Review Officer Do?
- DOT Drug Testing Process
- What Is the DOT Shy Bladder Procedure?
- What Is a Dilute Specimen?
- What Is an Adulterated Specimen?
Primary Authorities
Have a Question About Your MRO Review?
If you are waiting on an MRO determination or have a medical explanation to submit, a DOT qualified Substance Abuse Professional can help you understand the process.
Reviewed by: Perret deLapouyade, CEAP, SAP
Reviewed date: July 12, 2026
Updated date: July 12, 2026
BOK ID: BOK-0097
